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Drug Interactions The concomitant usage of benzodiazepines and opioids boosts the chance of respiratory despair due to steps at unique receptor web pages within the CNS that Command respiration. Benzodiazepines interact at GABAA websites and opioids interact primarily at mu receptors.CYP450 3A4 Interaction: The concomitant use with CYP450 3A4 inhib